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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SF3B1 All Species: 31.52
Human Site: T350 Identified Species: 57.78
UniProt: O75533 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O75533 NP_036565.2 1304 145830 T350 A S Q M G G S T P V L T P G K
Chimpanzee Pan troglodytes XP_516006 1379 153963 T425 A S Q M G G S T P V L T P G K
Rhesus Macaque Macaca mulatta XP_001086317 1397 156322 T443 A S Q M G G S T P V L T P G K
Dog Lupus familis XP_857149 1312 146628 T358 A S Q M G G S T P V L T P G K
Cat Felis silvestris
Mouse Mus musculus Q99NB9 1304 145798 T350 A S Q M G G S T P V L T P G K
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421912 1383 154834 T429 A S Q M G G S T P V L T P G K
Frog Xenopus laevis O57683 1307 146196 T353 A S Q M G G S T P V L T P G K
Zebra Danio Brachydanio rerio XP_684311 1315 147162 T361 A S Q M G S S T P L L T P G K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_623732 1315 147662 M344 S N Q T P G S M T P Q T P A T
Nematode Worm Caenorhab. elegans NP_497853 1322 147305 Q343 T P L H S G L Q T P S F T P S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa XP_002323970 1267 141858 I323 G P T P L G A I D M A T P T P
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_201232 1269 141432 I322 Y T P G V T P I G G I D M A T
Baker's Yeast Sacchar. cerevisiae P49955 971 110009 V125 E N S D S A L V N V E G I H D
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.5 93.3 99.3 N.A. 99.9 N.A. N.A. N.A. 93.7 96.6 93.7 N.A. N.A. 82.4 65.1 N.A.
Protein Similarity: 100 94.5 93.3 99.3 N.A. 100 N.A. N.A. N.A. 93.7 98.3 96.4 N.A. N.A. 88.9 76.6 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. N.A. 100 100 86.6 N.A. N.A. 33.3 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. N.A. 100 100 93.3 N.A. N.A. 46.6 6.6 N.A.
Percent
Protein Identity: 68.4 N.A. N.A. 68.3 40.4 N.A.
Protein Similarity: 79.3 N.A. N.A. 79.1 53.1 N.A.
P-Site Identity: 20 N.A. N.A. 0 6.6 N.A.
P-Site Similarity: 33.3 N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 62 0 0 0 0 8 8 0 0 0 8 0 0 16 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 8 0 0 8 0 0 8 % D
% Glu: 8 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 8 0 0 8 62 77 0 0 8 8 0 8 0 62 0 % G
% His: 0 0 0 8 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 0 0 0 0 16 0 0 8 0 8 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 62 % K
% Leu: 0 0 8 0 8 0 16 0 0 8 62 0 0 0 0 % L
% Met: 0 0 0 62 0 0 0 8 0 8 0 0 8 0 0 % M
% Asn: 0 16 0 0 0 0 0 0 8 0 0 0 0 0 0 % N
% Pro: 0 16 8 8 8 0 8 0 62 16 0 0 77 8 8 % P
% Gln: 0 0 70 0 0 0 0 8 0 0 8 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 8 62 8 0 16 8 70 0 0 0 8 0 0 0 8 % S
% Thr: 8 8 8 8 0 8 0 62 16 0 0 77 8 8 16 % T
% Val: 0 0 0 0 8 0 0 8 0 62 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _